ABC Transporters and Multidrug Resistance - download pdf or read online

By Ahcène Boumendjel, Jean Boutonnat, Jacques Robert

A accomplished evaluate of the most up-tp-date medical study on ABC transporters and multidrug resistance

ATP-binding cassette transporter genes (ABC transporters) are recognized to play a vital function within the improvement of multidrug resistance (MDR). MDR is the power of pathologic cells, akin to tumors, to resist chemical substances designed to focus on and smash such cells. In MDR, sufferers who're on medicine finally strengthen resistance not to in simple terms the drug they're taking, yet to numerous varieties of drugs.

ABC Transporters and Multidrug Resistance bargains a vital source for pharmaceutical researchers who're operating to find medicines to counteract multidrug resistance in illnesses resembling melanoma. in a single entire quantity, this ebook includes a selection of the most up-tp-date wisdom at the involvement of ABC transporters in drug shipping and resistance.

This entire quantity offers an outline at the description of the constitution, the genome, common tissue expression, physiological point, and mechanism of motion of the ABC protein. The specialist members discover the expression, detection, and implications of ABC proteins in hematological malignancies and good tumors and ABC proteins and pathogenic microorganisms. This quantity additionally explains MDR modulation via inhibition of ABC transporters and the layout of inhibitors and mechanism of motion. furthermore, the booklet bargains crucial details at the organic and scientific point of multidrug resistance.

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Extra resources for ABC Transporters and Multidrug Resistance

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Involvement of P-glycoprotein in the release of cytokines from peripheral blood mononuclear cells treated with methotrexate and dexamethasone. J Pharm Pharmacol 57: 1421–1425. 46. Siegsmund M, Brinkmann U, Scháffeler E, Weirich G, Schwab M, Eichelbaum M et al. 2002. Association of the P-glycoprotein transporter MDR1(C3435T) polymorphism with the susceptibility to renal epithelial tumors. J Am Soc Nephrol 13: 1847–1854. 47. Taniguchi S, Mochida Y, Uchiumi T, Tahira T, Hayashi K, Takagi K et al. 2003.

Differential regulation of MDR1 transcription by the p53 family members. Role of the DNA binding domain. J Biol Chem 280: 13213–13219. 38. Okamura H, Yoshida K, Sasaki E, Morimoto H, and Haneji T. 2004. Transcription factor NF-Y regulates mdr1 expression through binding to inverted CCAAT sequence in drug-resistant human squamous carcinoma cells. Int J Oncol 25: 1031–1037. 39. Chen GK, Sale S, Tan T, Ermoian RP, and Sikic BI. 2004. CCAAT/enhancerbinding protein beta (nuclear factor for interleukin 6) transactivates the human MDR1 gene by interaction with an inverted CCAAT box in human cancer cells.

Sarkadi B, Homolya L, Szakács G, and Váradi A. 2006. Human multidrug resistance ABCB and ABCG transporters: Participation in a chemoimmunity defense system. Physiol Rev 86: 1179–1236. 15. Huang Y and Sadée W. 2006. Membrane transporters and channels in chemoresistance and -sensitivity of tumor cells. Cancer Lett 239: 168–182. 16. Van Helvoort A, Smith AJ, Sprong H, Fritzsche I, Schinkel AH, Borst P et al. 1996. MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine.

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ABC Transporters and Multidrug Resistance by Ahcène Boumendjel, Jean Boutonnat, Jacques Robert

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